Solutions

The right infrastructure for every stakeholder

Principia pairs an RWD-native platform that speaks FHIR, OMOP, and SDTM/CDASH fluently with deep domain expertise, serving organizations across the health science ecosystem, from disease associations orchestrating multi-site research to biotech companies building their first registry.

Disease Associations

Orchestrate research networks that sustain your mission

Disease associations sit at the center of CuRE ecosystems. We help you build and operate multi-site research networks that capture data from member sites, integrate it into shared research assets, and deliver value back to participants — creating a sustainable exchange that drives adoption, data quality, and long-term network growth.

A platform purpose-built for multi-stakeholder research ecosystems — not a clinical trial tool repurposed for registries. Member sites contribute data and receive insights, analytics, and decision support tools that improve care quality.

What we deliver

  • Registry design, build, and lifecycle management via Control
  • Multi-site network orchestration with governed data sharing
  • Integrated data from EMRs (Conduit), labs, genomics, and PROs (Compass)
  • Stakeholder portals with benchmarking and analytics (Calculate)
  • Clinical decision support for member providers (Cue)
  • Patient engagement and disease support applications (Compass)

Academic Medical Centers

Outgrow spreadsheet-based tools without enterprise overhead

Academic research teams need modern infrastructure that scales beyond manual data collection — without the cost and complexity of enterprise clinical systems. Principia provides a research-grade platform at academic-friendly pricing, with OMOP-native architecture that integrates seamlessly with institutional data assets.

Modern research infrastructure that scales with your ambitions — without requiring a dedicated IT team or enterprise licensing. Built for academic workflows, priced for academic budgets.

What we deliver

  • Automated EMR data extraction via Conduit — replacing manual chart abstraction
  • OMOP-native data harmonization across departments and affiliates (Conduct)
  • Self-serve research enclaves with privacy controls (Calculate)
  • Methods library for reproducible, publishable analytics
  • Multi-institutional data federation without moving data
  • Standards-based interoperability (FHIR, OMOP, i2b2, SDTM/CDASH)

CGT & Rare Disease Sponsors

Purpose-built for small populations and complex translational data

Cell and gene therapy trials generate uniquely complex data — from apheresis and manufacturing through clinical outcomes and long-term follow-up. Principia's platform is optimized for the small-population, high-complexity reality of CGT and rare disease, linking manufacturing variables to clinical outcomes in ways general-purpose systems cannot.

A platform that understands the CGT data journey — from cell collection through manufacturing to patient outcomes — not a traditional EDC with translational bolted on.

What we deliver

  • Manufacturing-to-outcomes data linkage across the therapy lifecycle
  • Translational data integration: apheresis, manufacturing, clinical, genomics
  • Small-cohort analytics optimized for rare disease populations (Calculate)
  • Randomization and trial supply management for small-population trials (Cascade)
  • Long-term follow-up and safety surveillance (Canary)
  • Registry lifecycle management for post-market commitments (Control)
  • Patient-reported outcomes and eConsent for dispersed populations (Compass)

Emerging Biotech

Enterprise compliance without enterprise cost

Early-stage biotech companies need regulatory-grade infrastructure from day one, but can't absorb the cost and implementation timelines of legacy enterprise platforms. Principia delivers compliance-ready research infrastructure with rapid deployment — giving you the rigor investors and regulators expect at a fraction of the traditional price.

Get the data infrastructure of a top-20 pharma company — deployed fast, priced for your stage, and built to scale as your pipeline advances. No multi-year implementation. No per-seat surprises.

What we deliver

  • Rapid deployment — production-ready in weeks, not months
  • Regulatory-ready data capture and audit trails (Capture)
  • OMOP-native data from the start — no costly migration later
  • Scalable from single-site to multi-national as you grow
  • Integrated safety monitoring and SAE workflows (Canary)
  • Study lifecycle management without dedicated ops staff (Control)

Large Pharma — Observational Teams

A specialist platform for your real-world data workloads

Observational research and RWE teams inside large pharma often struggle with general-purpose clinical systems that weren't designed for real-world data. Principia provides a purpose-built RWD platform with OMOP-native architecture — designed from the ground up for the multi-source, longitudinal, and often messy reality of real-world evidence.

A specialist RWD platform that complements your existing clinical infrastructure — purpose-built for the observational workloads that general-purpose trial systems handle poorly.

What we deliver

  • OMOP-native architecture designed for RWD from day one (Conduct)
  • Multi-source data integration: EHR, claims, genomics, PROs, manufacturing
  • Real-world evidence generation and submission-grade analytics — SDTM/CDASH outputs (Calculate)
  • Risk-based quality management — centralized statistical monitoring and KRIs (Caliber)
  • Network-scale data access through established research ecosystems
  • Pharmacovigilance and post-market safety surveillance (Canary)
  • Site and patient network access for pragmatic trials

Providers & Health Systems

Participate in research without disrupting clinical workflows

Principia's technology automates research data capture directly from your EHR, eliminating manual abstraction burden while giving your clinicians access to evidence-based decision support and outcomes benchmarking — a clear value exchange for participating in research networks.

Research participation that gives back: contribute clinical data and receive decision support, outcomes benchmarking, and quality tools that directly improve care at your site.

What we deliver

  • Automated EHR data extraction via Conduit (SMART on FHIR)
  • Near-zero manual chart abstraction with AI-driven validation (Capture)
  • Clinical decision support at the point of care (Cue)
  • Quality metrics and outcomes benchmarking (Calculate)
  • Patient engagement and ePRO collection (Compass)
  • Standards-based integration that works with your existing systems

Cell & Gene Therapy

From cell collection to patient outcomes — one data thread

CGT and rare disease programs generate uniquely complex, multi-modal data across the therapy lifecycle. CuRE is designed to capture, link, and analyze this data end-to-end — enabling insights that siloed systems simply cannot produce.

Manufacturing Linkage

Connect manufacturing variables — cell source, processing parameters, release criteria — to downstream clinical outcomes in a single governed dataset.

Translational Integration

Unify apheresis, manufacturing, clinical, genomic, and biomarker data into a harmonized OMOP foundation — bridging bench-to-bedside in one platform.

Small Population Analytics

Analytics and visualization tools designed for the statistical realities of rare disease — where every patient matters and cohorts are measured in dozens, not thousands.

Long-term Follow-up

Continuous safety surveillance and patient-reported outcomes for the 5-, 10-, and 15-year follow-up commitments that CGT regulators require.

Discuss your CGT program

Advisory & Consulting

Strategic services that complement our technology

Beyond our platform, Principia provides consulting and advisory services rooted in decades of experience building health science data systems and research networks.

System Architecture & Design

Design scalable, standards-based research data infrastructure. We help organizations architect systems that grow with their needs while maintaining interoperability and data quality.

Enterprise Transformation

Modernize research operations and organizational models. From legacy system migration to operational redesign, we guide organizations through complex transformations.

Research Innovation & Automation

Strategy for automating data capture and accelerating scientific discovery. We identify opportunities to leverage technology for research efficiency gains.

Study Design & Facilitation

Design and facilitate studies that leverage integrated real-world data assets. We help maximize the value of existing data while planning for new collection.

Solution Architecture & Implementation

End-to-end solution design and implementation. We work with your teams to select, configure, and deploy the right technology for your specific challenges.

Data Integration Strategy

Plan and execute multi-source data integration initiatives. We help organizations bring together clinical, genomic, claims, and other data types into unified research assets.

Let's discuss your needs

Every organization has unique challenges. We'll help you identify the right combination of technology and expertise.

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