Principia Health SciencesInsights on outcomes research, real-world evidence, and health data technology.https://principia.health/The CuRE Early Access Programhttps://principia.health/resources/blog/early-access-program/https://principia.health/resources/blog/early-access-program/CuRE, Principia's Collaborative Research Ecosystem platform, opens to early-access teams at the 2026 OHDSI Global Symposium: 25 apps on one governed OMOP record, free to explore, with a 90-day trial that starts when you bring real data.Mon, 19 Oct 2026 00:00:00 GMTA Governed Superset of the OHDSI Stack: CuRE at OHDSI's 2026 Global Symposiumhttps://principia.health/resources/blog/cure-at-ohdsi-2026/https://principia.health/resources/blog/cure-at-ohdsi-2026/CuRE's clinical data is OMOP from the first record and integrates tightly with OHDSI tools (e.g., ATLAS can register it as a CDM source). Here is some of what we will show at OHDSI's 2026 Global Symposium.Tue, 06 Oct 2026 00:00:00 GMTWhat Integrated Health Science Data Can Answerhttps://principia.health/resources/whitepapers/value-of-integrated-health-science-data/https://principia.health/resources/whitepapers/value-of-integrated-health-science-data/A whitepaper on why tightly integrated research infrastructure changes the questions sponsors, sites, and research networks can ask.Thu, 11 Jun 2026 16:00:00 GMTWhy a Research Platform Should Be One Integrated System, Not a Bucket of Incongruous Toolshttps://principia.health/resources/blog/one-system-not-twelve-tools/https://principia.health/resources/blog/one-system-not-twelve-tools/Most research stacks are a collection of products bolted together with flat files and nightly reconciliation. CuRE takes the opposite bet: one governed record, every product on the same substrate, AI built in from the start.Wed, 20 May 2026 00:00:00 GMTWhy Legacy EDC Is Holding Back Outcomes Researchhttps://principia.health/resources/blog/why-legacy-edc-is-holding-back-outcomes-research/https://principia.health/resources/blog/why-legacy-edc-is-holding-back-outcomes-research/Electronic data capture was built for clinical trials, not for the messy, longitudinal reality of outcomes research. It's time we stopped pretending otherwise.Fri, 10 Apr 2026 00:00:00 GMTWhat We Mean by Collaborative Research Ecosystemshttps://principia.health/resources/blog/collaborative-research-ecosystems/https://principia.health/resources/blog/collaborative-research-ecosystems/The future of outcomes research isn't a better database — it's a shared infrastructure where patients, providers, researchers, and industry work from the same foundation.Sat, 28 Mar 2026 00:00:00 GMTThe Real-World Evidence Generation Gaphttps://principia.health/resources/blog/real-world-evidence-generation-gap/https://principia.health/resources/blog/real-world-evidence-generation-gap/Everyone agrees RWE is the future. Almost nobody has the infrastructure to generate it systematically. Here's what's missing.Sun, 15 Mar 2026 00:00:00 GMTThe Economics of Real-World Evidence: Why Legacy EDC Costs 10x What It Shouldhttps://principia.health/resources/whitepapers/economics-of-real-world-evidence/https://principia.health/resources/whitepapers/economics-of-real-world-evidence/A detailed analysis of the true cost of outcomes research infrastructure — and how purpose-built platforms can reduce it by an order of magnitude.Sun, 15 Feb 2026 00:00:00 GMT